Precision-guided antimicrobial peptide as a targeted modulator of human microbial ecology
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چکیده
منابع مشابه
Precision-guided antimicrobial peptide as a targeted modulator of human microbial ecology.
One major challenge to studying human microbiome and its associated diseases is the lack of effective tools to achieve targeted modulation of individual species and study its ecological function within multispecies communities. Here, we show that C16G2, a specifically targeted antimicrobial peptide, was able to selectively kill cariogenic pathogen Streptococcus mutans with high efficacy within ...
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Within the repertoire of antibiotics available to a prescribing clinician, the majority affect a broad range of microorganisms, including the normal flora. The ecological disruption resulting from antibiotic treatment frequently results in secondary infections or other negative clinical consequences. To address this problem, our laboratory has recently developed a new class of pathogen-selectiv...
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The role of LL-37, a human cationic antimicrobial peptide, in the immune system is not yet clearly understood. It is a widely expressed peptide that can be up-regulated during an immune response. In this report, we demonstrate that LL-37 is a potent antisepsis agent with the ability to inhibit macrophage stimulation by bacterial components such as LPS, lipoteichoic acid, and noncapped lipoarabi...
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Microbial ecology and dysbiosis are topics worthy of study. This review article will be the first of a two-part series that will discuss normal flora and threats to its ecology resulting in dysbiosis. Microorganisms are generally required to attain critical population increases before they threaten the host. The research on the role of bacterial microorganisms which are considered to be part of...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2015
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1506207112